New endometrial cancer therapy reported

by United Press International (

PHOENIX (UPI) — U.S. scientists say they have found a new way to treat endometrial cancer — cancer of the uterine lining — that slows tumor growth and kills cancer cells.

Researchers at the Translational Genomics Research Institute in Phoenix and the Washington University School of Medicine in St. Louis said they found that introducing a particular inhibitor drug can turn off’ receptors responsible for the growth of tumors in a significant number of patients with endometrial cancer.

They said they also determined the inhibitor drug proved effective even in cancer tumors containing a commonly occurring mutant gene, PTEN, previously associated with resistance to drug treatment.

The scientists, led by Drs. Pamela Pollock and Paul Goodfellow, a Washington University professor, said they used the latest genome-scanning technology to sequence 116 endometrial tumor samples in conducting the research. They said they plan to begin a clinical trial within the next year.

The findings are detailed as a priority report in the journal Cancer Research.


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